منابع مشابه
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis.
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in the nervous system, where it is involved in neuronal migration, synaptic transmission, and survival. The role of Cdk5 in synaptic transmission is mediated by regulating the cellular functions of presynaptic proteins such as synapsin, Munc18, and dynamin 1. Its multifunctional role at the synapse is complex and probably involves othe...
متن کاملThe septin Sept5/CDCrel-1 competes with α-SNAP for binding to the SNARE complex
SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) proteins are supposed to mediate the docking and/or fusion of the vesicle with the plasma membrane. However, it is not clearly understood how this process is regulated. In a search for potential SNARE regulators, we recently identified septin 5 (Sept5) as a novel SNARE interacting protein. Septins were first i...
متن کاملMechanisms of Septin-mediated Inhibition of Neurotransmitter Release
Neurons communicate at chemical synapses via exocytosis of synaptic vesicles containing neurotransmitter, a process mediated by SNARE proteins. SEPT5, a predominantly brainspecific member of the septin family of GDP/GTP-binding cytoskeletal proteins, binds the SNARE STX1A. Furthermore, SEPT5 inhibits exocytosis and has been implicated in the organization of synaptic vesicles within the presynap...
متن کاملSuperfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.
The septin family of GTPases, first identified for their roles in cell division, are also expressed in postmitotic tissues. SEPT3 (G-septin) and SEPT5 (CDCrel-1) are highly expressed in neurons, enriched in presynaptic terminals, and associated with synaptic vesicles. These characteristics suggest that SEPT3 or SEPT5 might be important for synapse formation, maturation, or synaptic vesicle traf...
متن کاملHuman septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.
Septins are a cytosolic GTP-binding protein family first characterized in yeast, but gaining increasing recognition as critical protagonists in higher eukaryotic cellular events. Mammalian septins have been associated with cytokinesis and exocytosis, along with contributing to the development of neurological disorders. Ten different septins, divided into four groups, have been identified in mam...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37612